The 50/50 works as it doesnt need a lot of tuning. But.. it has the issue of damage to blower and hydrolock. When the volume injected starts going up.
The straight meth works. If you look into the LS1 crowd with the 4th gens, trucks, Vette's that use the Magnusson blowers you'll see a pettern there. They use straight alcohol and tune the engines in no problem.
Your L67 I believe the issue is tunability afforded. Meaning the ability to making changes to injector pulse width to make up for the extra fuel the methanol injects. Years ago I had a customer who developed weird issues tuning the computer on his L67. As he would pull injector PW, his car would start to short shift. The explanation at the time was the GM computer would see a lower than anticipated PW and since it also controls the transmission, would cuase the condition protecting itself. Kind of like the computer sees 15 PSI boost, 5000 RPM's, it expects "X" amount of fuel. When it sees 20% less than "X", it short shifts.. I dont know if those issues are addressed with the current versions of software by HP, EFI live, etc.. Not having an L67 to play with, or having shops with L67 based engines its hard to develop "fixes" for a market that is small.
Meaning the L67 is a niche market, few shops, and more set in their ways. Let alone the owners have a push for trying to buy the least expensive systems they can get away with. So the end result is poor performance, unpredictable results, and the current state of mind.
Coupled with other issues like the TB/Maf issue so nozzles get complicated. Cars losing value, part replacements getting higher, its tough.
HTH