I have run it from everything from windows 95 up to XP, vista I personally have not ran turbolink from, but others say they have with the user account turned off on the computer.
Those USB to serial cables are picky, I have used several that did not work but the IO Gear ones seem to always work. Sometimes for some reason you need to go into the device manager when the cable is plugged in and change some settings. Make sure you have the right drivers loaded to for the USB cable. If you do a search over on GNTTYPE.org forum, there are several posts on helping you out.