Start tuning rich then work your way up leaning it out. A good starting point is 10.5:1 air fuel. See how much power it makes, then move it up.. 10.6, 10.7, 10.8.. keep moving it up as power increases with no other changes. Once you find what makes the most amount of power, back it down a touch. So if motor is fastest at 11.3, go down to 11.1-11.2. Every motor is different, so work on it.
My engine is run at 10.5:1 has 160 passes so far zero issues. It will make more power at 11.0:1 but a little fatter keeps things together.
There is an old saying, candle that burns sooo bright does not burn for so long
Same goes with timing. Once you reach your comfort zone on airfuel, then start to increase timing.