I know what Kenny Dutweiller would tell you....."Are you crazy? Intercool the thing!"
How much boost you going to run? If only 10-15 psi, I would run E85 w/o intercooler. Think of E85 as a chemical intercooler. Just be sure you have capable injectors and fuel system. FWIW, I'm told that E85 LIKES to run rich, not lean.
You are going to run FAST aren't you! I have the FAST Touch Screen and can monitor and log A/F on the fly w/o laptop. It is great!!
Also, run aluminum Stage heads.
One final thought, if you don't want all the piping with air-to-air intercooler, how aboyut an air-to-water intercooler. My Ford Lightning has air-to-water and it works great!
Conrad